Private and Public Partners Unite to Combat 10 Neglected Tropical Diseases by 2020

LONDON, Jan. 30, 2012 /PRNewswire via African Press Organization (APO)/ — Partners pledge innovative, coordinated action aimed at new World Health Organisation goals

Today, 13 pharmaceutical companies, the U.S., U.K. and U.A.E governments, the Bill & Melinda Gates Foundation, the World Bank and other global health organisations announced a new, coordinated push to accelerate progress toward eliminating or controlling 10 neglected tropical diseases (NTDs) by the end of the decade.

Uniting efforts with NTD-endemic countries, partners pledged to bring a unique focus to defeating these diseases and to work together to improve the lives of the 1.4 billion people worldwide affected by NTDs, most of whom are among the world’s poorest.

In the largest coordinated effort to date to combat NTDs, the group announced at an event at the Royal College of Physicians that they would: sustain or expand existing drug donation programs to meet demand through 2020; share expertise and compounds to accelerate research and development of new drugs; and provide more than US$785 million to support R&D efforts and strengthen drug distribution and implementation programmes. Partners also endorsed the “London Declaration on Neglected Tropical Diseases,” in which they pledged new levels of collaborative effort and tracking of progress.

“Today, we have joined together to increase the impact of our investments and build on the tremendous progress made to date,” said Bill Gates, co-chair of the Bill & Melinda Gates Foundation. “This innovative approach must serve as a model for solving other global development challenges and will help millions of people build self-sufficiency and overcome the need for aid.” The Gates Foundation announced a five-year, US$363 million commitment to support NTD product and operational research.

To guide the effort against NTDs, the World Health Organisation (WHO) this week unveiled a new strategy, Accelerating work to overcome the global impact of neglected tropical diseases-A roadmap for implementation [ ], that sets targets for what can be achieved by the end of the decade.

“The efforts of WHO, researchers, partners, and the contributions of industry have changed the face of NTDs. These ancient diseases are now being brought to their knees with stunning speed,” said Dr. Margaret Chan, Director-General of the WHO. “With the boost to this momentum being made today, I am confident almost all of these diseases can be eliminated or controlled by the end of this decade.”

New commitments from partners will close the funding gap to eradicate Guinea worm disease and expedite progress toward the 2020 goals of elimination for lymphatic filariasis, blinding trachoma, sleeping sickness and leprosy, and control of soil-transmitted helminthes, schistosomiasis, river blindness, Chagas disease and visceral leishmaniasis.

Speaking on behalf of the CEOs of the 13 pharmaceutical companies involved, Sir Andrew Witty, CEO of GlaxoSmithKline, said, “Many companies and organisations have worked for decades to fight these horrific diseases. But no one company or organisation can do it alone. Today, we pledge to work hand-in-hand to revolutionize the way we fight these diseases now and in the future.”

With new and existing pledges totaled, companies will donate an average of 1.4 billion treatments each year to those in need, according to the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA). In addition, new research and development collaborative efforts and access agreements with 11 companies and the R&D organisation Drugs for Neglected Diseases initiative (DNDi) are providing unprecedented access to compound libraries that could lead to new treatments. These commitments will work in parallel with other efforts to speed the development of critical NTD treatments, including WIPO Re:Search, a database of research compounds, knowledge and expertise.

To close the funding gap for Guinea worm eradication, His Highness Sheikh Khalifa bin Zayed Al Nahyan, President of the United Arab Emirates, the Gates Foundation, and the Children’s Investment Fund Foundation, will donate US$40 million to The Carter Center. These commitments complement an October pledge from the U.K. Department for International Development (DFID) that it would contribute pounds 20 million if others come forward-part of a four-year, pounds 195 million commitment to NTDs announced by DFID last week.

The U.S. Agency for International Development (USAID) also announced an $89 million appropriation by the U.S. Congress to strengthen drug delivery and distribution programmes, building on its US$212 million investment since 2006. In addition, the World Bank will extend its financing and technical support to help African countries build stronger community health systems that will integrate NTD elimination and control, as well as work with other partners to expand a trust fund to combat river blindness to other preventable NTDs in Africa.

“The world has come together to end the neglect of these horrific diseases which needlessly disable, blind and kill millions of the world’s poorest,” said Stephen O’Brien, U.K. Minister for International Development. “Britain and other partners are leading the way to provide critical treatments to millions of people, which allow children to attend school and parents to provide for their families so that they can help themselves out of poverty and eventually no longer rely on aid.”

Today’s pledges and Declaration come in response to WHO’s 2010 report, Working to overcome the global impact of neglected tropical diseases [ ], which called for new resources to overcome NTDs. Representatives from the pharmaceutical industry, the Gates Foundation and other partners worked during the past year to develop this expanded, coordinated effort.

The governments of Bangladesh, Brazil, Mozambique and Tanzania, where NTDs are endemic, announced that they would implement integrated plans to defeat NTDs and devote political and financial resources to combat these diseases. All partners pledged accountability by exploring mechanisms to regularly track progress toward the 2020 goals.

“From the moment the evidence of the very heavy burden of NTDs in Mozambique was understood, the government of Mozambique has taken action and continuously increased its commitment and investment to control or eliminate these diseases,” said Dr. Alexandre Manguele, Minister of Health of Mozambique. “With the resources pledged today in the context of this partnership the government of Mozambique feels ever more assured that the mission can be accomplished.”


Sustaining, Expanding and Extending Drug Supply:

– All companies with NTD drug donation programs pledged to sustain

or extend their programs to the end of the decade, and some

pledged to increase their commitments. These commitments include

the following:

– Sanofi, Eisai and the Bill & Melinda Gates Foundation will

work together to provide 120 million DEC tablets to the WHO

for their Global Lymphatic Filariasis Elimination programme.

Combined with Eisai’s donation commitment that will start in

2014, these new tablets will ensure a sufficient supply of

DEC from 2012 through 2020.

– Bayer will double its existing donation of nifurtimox to

treat Chagas disease.

– Eisai will extend its existing donation of 2.2 billion

tablets of DEC for LF to 2020.

– Gilead, which announced a donation of AmBisome for visceral

Leishmaniasis in 2011, will continue its program to offer VL

at cost and commit to investigate and invest in technologies

and processes that could reduce that cost in resource-

limited countries.

– GlaxoSmithKline will extend its existing donation of

albendazole to treat soil-transmitted helminthes by

providing 400 million tablets per year for an additional

five years to 2020, as well as continuing its donation of

600 million tablets per year to combat lymphatic filariasis.

– Johnson & Johnson will extend its existing donation of

mebendazole for soil-transmitted helminthes by providing 200

million tablets per year to 2020.

– MSD will continue its unlimited donation of ivermectin to

combat river blindness and lymphatic filariasis (where

co-endemic with river blindness), as well as discuss the use

of ivermectin to combat other diseases.

– Merck KGaA will significantly increase its annual donation

of praziquantel tablets from 25 million to 250 million

tablets per year, extending the program indefinitely.

– Novartis will extend its commitment to provide multi-drug

Therapy (rifampicin, clofazimine and dapsone) to leprosy

patients worldwide in a final push against the disease.

– Pfizer will continue its donation of azithromycin for

blinding trachoma until at least 2020, as well as donate the

drug and placebo to a study on the reduction in mortality of

children treated with azithromycin.

– Sanofi will extend its existing donation of eflornithine,

melarsoprol and pentamidine for sleeping sickness to 2020,

as well as logistical support to ensure that the drugs

continue to reach patients at the point of care cost-free.

Accelerating R&D for New Treatments:

– Product development partnerships under the coordination of DNDi

with Abbott, Johnson & Johnson and Pfizer are underway to develop

new drugs to treat helminth infections, notably a

macrofilaricide, which kills adult worms that cause river

blindness and lymphatic filariasis.

– Abbott is conducting initial drug reformulation studies and

providing scientific expertise for preclinical development,

with technical and supply assistance from Johnson & Johnson.

– If pre-clinical development is successful, Johnson & Johnson

will co-fund clinical development, and collaborate with

other partners, including technical support from Pfizer’s

staff scientists. J&J would obtain regulatory approval.

– Innovative licensing or collaboration agreements with DNDi by 11

companies-Abbott, AstraZeneca, Bayer, Bristol-Myers Squibb,

Eisai, GlaxoSmithKline, Johnson & Johnson, MSD, Novartis, Pfizer

and Sanofi-are in negotiation or underway for the sharing of

compounds and knowledge in order to generate new drugs for

diseases including river blindness, lymphatic filariasis,

sleeping sickness, Chagas disease and visceral leishmaniasis.

– DNDi and Sanofi announced a product development collaboration to

co-develop a new drug candidate for sleeping sickness,

oxaborole/SCYX-7158, in addition to fexinidazole, which is

already in clinical development.

Increasing funding to improve drug product and operational research, delivery and implementation programmes, including prevention, monitoring and education:

– Several partners announced US$40 million in new funding to The

Carter Center that will close the gap to eradicate Guinea worm.

The Gates Foundation will contribute US$23.3 million, His

Highness Sheikh Khalifa bin Zayed Al Nahyan, President of the

United Arab Emirates, will contribute US$10 million and the

Children’s Investment Fund Foundation will contribute US$6.7


– This funding complements pounds 20 million in funding from DFID,

Announced last week as part of a pounds 195 million commitment

through 2015, targeted at Guinea worm disease, lymphatic

filariasis, river blindness and schistosomiasis, as well as

developing new programmes for blinding trachoma, visceral

leishmaniasis, research and integrated country approaches.

– The Gates Foundation announced a 5-year, US$363 million

commitment to overcome barriers to success and address critical

gaps to achieve the control and elimination of targeted NTDs by


– USAID will continue support to over 20 countries to introduce

and/or scale up integrated NTD programs, including three new

countries: Mozambique, Senegal and Cambodia. The U.S. Congress

appropriated $89 million to USAID for NTD control in FY2012.

– At the country level, the World Bank will extend its financing

and technical support to help countries build stronger community

health systems that will integrate NTD elimination and control.

At the regional level, the World Bank will continue fiduciary

oversight of the existing trust fund that supports the fight

against river blindness in Africa, and will also work with other

partners to expand the trust fund to eliminate or control

preventable NTDs on the continent.

– Mundo Sano contributed US$5 million to expand work in NTD control

and program enhancement for selected sites in the Americas and


– The Government of Mozambique announced specific goals for NTD

control and elimination in endemic areas of the country,


– Reaching full geographic coverage of all endemic areas for

lymphatic filariasis, soil-transmitted helminthes and


– Completely mapping and reaching full geographic coverage of

trachoma by 2018

– Building capacity for surveillance and action to sustain

gains from mass drug administration programs

– The Governments of Brazil, Tanzania, Bangladesh and other NTD-

Endemic countries announced implementation of fully integrated or

coordinated plans to control and eliminate NTDs in their


– Three pharmaceutical companies-Merck KGaA, Novartis and Sanofi-

will organize and provide funding to support prevention,

monitoring, education and intensified disease control efforts.

– Lions Clubs International announced US$6.9 million in funding to

support the Government of China in efforts to eliminate blinding

trachoma by 2017.

Coordinating and measuring NTD commitments: Industry partners pledged to work together toward the achievement of the 2020 goals. Based on the WHO roadmap, partners will follow collective progress through a scorecard that will regularly and formally track progress including whether participating organisations are meeting their supply, research, funding and implementation commitments to work toward the 2020 goals. This process will ensure accountability and transparency and identify remaining gaps.

Speakers at today’s event at the Royal College of Physicians include:

– Dr. Margaret Chan, Director-General, World Health Organisation

– Bill Gates, Co-Chair, Bill & Melinda Gates Foundation

– Stephen O’Brien, Parliamentary Under-Secretary of State, UK

Department for International Development

– Dr. Ariel Pablos-Mendez, Assistant Administrator for Global

Health, US Agency for International Development

– Dr. Jorg Reinhardt, Chairman of the Board of Management, Bayer

HealthCare AG

– Lamberto Andreotti, Chief Executive Officer, Bristol-Myers Squibb

– Haruo Naito, President and CEO, Eisai

– Sir Andrew Witty, Chief Executive Officer, GlaxoSmithKline

– William Weldon, Chairman, Board of Directors and Chief Executive

Officer, Chairman, Executive Committee, Johnson & Johnson

– Kenneth Frazier, Chairman of the Board, President and Chief

Executive Officer, MSD

– Dr. Stefan Oschmann, Executive Board member, Merck KGaA, with

Responsibility for the Pharmaceuticals business sector

– Joseph Jimenez, Chief Executive Officer, Novartis

– Christopher A. Viehbacher, Chief Executive Officer, Sanofi

– Paul Carter, Senior Vice-President, International Commercial

Operations, Gilead

– Dr. Bernard Pecoul, Executive Director, Drugs for Neglected

Diseases initiative

– Dr. Caroline Anstey, Managing Director, World Bank

– Dr. AFM Ruhal Haque, Minister of Health and Family Welfare,


– Jarbas Barbosa da Silva, Jr., Vice Minister for Health

Surveillance, Ministry of Health, Brazil

– Dr. Alexandre Lourenco Jaime Manguele, Minister of Health,


– Dr. Donan Mmbando, Director of Preventive Services, Ministry of

Health and Social Welfare, Tanzania

A webcast of this event can be viewed at

For supplemental materials and information about the foundation’s work, please visit:

SOURCE Global Health Strategies

CONTACT: Victor Zonana, Global Health Strategies, +44(0)75-5380-9731, [email protected]

Be the first to like this post.



Please enter your comment!
Please enter your name here

This site uses Akismet to reduce spam. Learn how your comment data is processed.