Ten Ghanaian players have their clubs in this season?s Group phase of the UEFA Champions League.
Group E-which has Chelsea, Nordsj?lland, Juventus and Shakhtar Donetsk-is likely to face five Ghanaian players in action.
If out-of-favour Michael Essien remains at Stamford before the the transfer window shuts on Friday he will be in contention.
The midfielder has been on the bench in Chelsea opening three matches of the season.
His future has been speculated and the 29-year-old has been linked with a move to Fenerbahce.
Italian champions Juventus have midfield gem Kwadwo Asamoah and youngster Richmond Boakye-Yiadom if he stays.
Danish champions Nordsj?lland will present Enoch Adu Kofi and new signing Kamal Issah.
Romanian champions CFR Cluj-who have signed Ghana Under-20 midfielder Godfred Adofo-face a daunting task against Manchester United, Sporting Braga and Galatasary.