The 40-year-old will be in charge when the two giants clash at the Borg El Arab stadium with a massive 50,000 fans expected to attend the game.
He will be assisted by compatriot Theophille Vinga and Serge Meye.
The referee became a FIFA referee in 2011 and CAF elite referee since November of the same year.
Otogo-Castane is familiar to Ghanaians as he was the referee when the four-time African champions were beaten by Mali in the third placed match in the 2013 Africa Cup of Nations in South Africa.
The two nations go toe-to-toe in the North African country with the Egyptian desperate to pick another three points to enhance their chances of qualifying to Russia 2018.
They managed a hard-fought 2-1 win at Congo while Ghana struggled to a dull 0-0 against Uganda at home in their opening fixtures respectively.
The Pharaohs also want to avenge the 7- 2 aggregate defeat suffered from the Black Stars during the 2014 World Cup qualifying campaign.
By Sammy Heywood Okine