The opening goal boosted the confidence of the home side and pushed more men forward.
The Medeama lads earned a free-kick at the vital area of the visitors and Abass Mohammed converted it to score the second goal of the match on the 23rd minute, to cushion their lead.
After recess, the Sudanese pushed more men forward to find a consolation but the defence men of Medeama was resolute and thwarted all the incursions the visitors made into their vital area.
Coach Tom Strands of Medeama made some substitutions in the second half to solidify the mid-field and brought in Bismark Oppong for Samuel Bio.
The Coach of Al Shandy Ricardo Ferera also made some substitutions in a bid to find a consolation goal, but brilliant display by goalkeeper Mongtari Tagoe of Medeama prevented them from scoring.
The Medeama lads defended gallantly until 90 minute to secure a crucial win, and thus, making them the only Ghanaian club remaining in the CAF inter-club competitions after Obuasi Ashgold was bundled out of the CAF Champions League.
By Godwill Arthur-Mensah, GNA